Functional imaging of the healthy brain can delineate correlates of music processing

Anti-diabetic Compound Library manufacturer but cannot distinguish critical correlates from those that may be epiphenomenal. Human diseases that affect music processing therefore constitute potentially informative ‘experiments of nature’; however, most diseases produce substantial associated brain damage impacting on non-musical functions or (like stroke) they affect musical processing mechanisms stochastically. bvFTD is an ideal model system with which to address core biological functions of music: this disease selectively affects complex human social behaviours while sparing many other aspects of cognition, and targets a large-scale intrinsic brain network that links sensory experience with affective, semantic and reward processing (Seeley et al., 2007; Zhou et al., 2010, 2012; Raj et al., 2012). It has been demonstrated that neural structures predominantly implicated in bvFTD include long Von Economo projection neurons linking insular, cingulate and prefrontal cortices and subcortical centres (Seeley et al., 2012). Humans are one of a small number of species that possess these neurons and they appear to serve as a critical

substrate for MK-2206 nmr complex social behaviour. The network bound by these neurons has also been shown to be integral to music processing (Blood and Zatorre, 2001; Omar et al., 2011). Previously this was somewhat paradoxical, as the evolutionary value of music remains speculative (Mithen, 2005). The present findings in bvFTD raise the possibility that the modelling of mental states may be a core neurobiological function of music. This interpretation is in line with accumulating neurobiological and ethnographic evidences (Levitin, 2007). It has been proposed that music played a specific role in decoding others’ emotion states during human evolution (Mithen, 2005). Recognition of emotion in music engages components of the brain

network previously implicated in mentalising (Rankin et al., 2006; Zahn et al., 2007, 2009; Eslinger et al., 2011) and behavioural findings in autism and other disorders of social conduct have previously suggested that music influences mentalising PJ34 HCl (Bhatara et al., 2009; Heaton and Allen, 2009). We propose that, precisely on account of its abstract, inanimate nature, music may be highly effective in conveying certain kinds of signals relevant to mentalising: whereas actual social interactions are often highly complex with many potentially relevant variables, music might allow such interactions to be presented in a reduced, surrogate form that isolates elements critical for mentalising with low behavioural cost (Warren, 2008). A capacity to use music in this way would likely enhance empathy and pair-bonding and might therefore have been selected during human evolution (Mithen, 2005; Warren, 2008).