97) and larger CD4 count increases (pooled nonstandardized difference 39 cells/μL) compared with placebo. OBT genotypic sensitivity scores (GSSs) were also associated with larger differences in virological suppression (P<0.001 for GSS=0,≤1 and ≤2) and CD4 cell count increase (GSS=0, P<0.001; GSS ≤1, P=0.002; GSS ≤2, P=0.015) between the two GDC-0199 datasheet groups. CCR5 inhibitors were not associated with significant gains in CD4 cell counts (P=0.22) compared with other new drugs. Our study confirmed

the overall immunological and virological efficacy of new antiretroviral drugs in treatment-experienced patients, compared with placebo. The main predictive factor for efficacy was the number of fully active drugs. CCR5 inhibitors did not increase CD4 cell count to a greater extent than other new drugs. Recent improvements in the immunological and virological efficacies of available combination antiretroviral therapy (cART) regimens [1,2] have dramatically reduced morbidity and mortality among HIV-infected

patients [3–6]. Recent data, however, show that relative mortality rates among HIV-infected patients increase with duration of infection [6]. This long-term excess mortality may be related to the fact that longer time on cART may be associated with an increase in toxicity, resistance and nonadherence. HIV drug resistance, particularly multidrug class-wide http://www.selleckchem.com/products/r428.html resistance, is also associated with an increased incidence of AIDS-defining events and death [7]. The emergence of new antiretroviral drugs has increased the number of treatment options and improved the durability, tolerability and long-term efficacy of cART, even among patients with extensive treatment experience and high levels of drug resistance [8]. Managing these patients has also become more challenging, however. For instance, should their cART regimens contain two or three fully active drugs? Should regimens with at least three fully active

drugs include nucleoside reverse transcriptase Depsipeptide inhibitors (NRTIs)? Most guidelines remain vague, recommending regimens ‘consisting of two, or preferably three, fully active agents’ [9]. It is important to identify the patient characteristics and prognostic factors associated with higher cART efficacy, as they often help to determine which strategy to adopt when individual patients initiate new regimens. In a few pivotal trials comparing new antiretroviral drugs with placebo, subgroup analyses were performed to assess these factors, but most were not powered to show significant effects between subgroups [10,11]. New drug classes, such as chemokine (C-C motif) receptor 5 (CCR5) inhibitors and integrase inhibitors [12,13], which target different steps in the HIV replication cycle, may further alter HIV care. Some studies suggest that CCR5 inhibitors may increase CD4 cell count more dramatically than other new antiretroviral drugs [14].