and significantly decreased serotonin turnover in the PFC After correcting for multiple comparisons. chronic FIX treatment did not significantly alter erythrocyte fatty acid composition in male or female rats Chronic FIX treatment significantly and selectively increased docosapentaenoic acid (22.5n-6) in the PFC of female rats, but not in male rats These preclinical findings do not support the hypothesis buy Avapritinib that chronic FIX treatment increases n-3 fatty acid biosynthesis

or membrane composition (C) 2010 Elsevier Inc All rights reserved.”
“Background Rates of obesity are increasing worldwide, including in sub-Saharan Africa. Neonates born to obese mothers in low-income settings are at increased risk of complications including admission to neonatal

intensive care, macrosomia, low Apgar scores, and perinatal death. We investigated whether maternal obesity is a risk factor for neonatal death in sub-Saharan Africa and the effect on the detailed timing of death within the neonatal period.

Methods Cross-sectional Demographic and Health Surveys from 27 sub-Saharan countries (2003-09) were pooled. We used multivariable logistic regression to assess the risk of neonatal death (in women’s most recent singleton livebirth in the 5 years preceding the survey) by buy MG-132 maternal body-mass index (BMI) category (measured during the survey). Timing Bcl-w of death was investigated with

a discrete-time survival model.

Findings 15 518 of 81 126 eligible women were overweight (4266 were obese), 52 006 had an optimum BMI, and 13 602 were underweight. Maternal obesity was associated with an increased odds of neonatal death after adjustment for confounding factors (adjusted odds ratio 1.46, 95% CI 1.11-1.91). Maternal obesity was a significant risk factor for neonatal deaths occurring during the first 2 days of life (1.62, 1.11-2.37). We noted no statistically significant relation later in the neonatal period (days 2-6 1.36, 0.84-2.21; days 7-27 1.19, 0.65-2.18), possibly because of low statistical power.

Interpretation Maternal obesity in sub-Saharan Africa is associated with increased risk of early neonatal death. Potential mechanisms include prematurity, intrapartum events, or infections. Strategies to prevent and reduce obesity need to be considered; obese women should be advised to deliver in a health-care facility that can provide emergency obstetric and neonatal care.”
“This naturalistic study explored long-term effectiveness of adjunctive lamotrigine therapy for bipolar II depression. We analyzed prospective data from 109 lamotrigine-treated outpatients with bipolar II depression inadequately responsive to mood stabilizers Lamotrigine was added to prior treatment in a naturalistic fashion.