04 and stata statistical software (Version 60, College Station,

04 and stata statistical software (Version 6.0, College Station, TX). The statistical significance of differences in dichotomous variables was determined by using χ2 tests with Fischer’s two-tailed exact test, and by using t-test or U-test of Mann–Whitney for quantitative variables. All variables correlated

in univariate analysis with imported malaria were included in a stepwise backward regression model (significance level for exclusion of p≥ 0.25) to identify predictors of the disease. Logistic regression analysis was performed by stata statistical software (Version 6.0). The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were determined. A total of 272 travelers, mTOR inhibitor 54 malaria cases and 218 controls, were included. The M/F ratio was 1.34 (116 F and 156 M), and the mean age 37.4 (±11.9) years. They consisted of 152 tourists (55.9%), 58 immigrants (21.3%), 33 expatriates (12.1%), and 29 business travelers (10.7%). The following regions were visited: Africa (n = 169; 62.1%), Asia (n = 47; 17.3%), America (n = 14; 5.1%), and Caribbean (n = 12; 4.4%). The median duration of travel was 15 days (1–1095 days). Forty-seven patients (17.3%)

stayed in the tropics for more than 3 months. The median interval between return and presentation was 6 days (1–151 days). The median lag time between the onset of the symptoms and presentation was 7.5 days (1–90 days). Symptoms BI 6727 ic50 started during travel in 38%

of our patients. Seventy-three percent of the patients had taken medical advice before travel (general practitioner 7%; specialist in tropical disease 61.8%; travel agency 3.3%; telephonic center 1.5%). The chemoprophylaxis was inadequate in 170 cases (62.5%), regarding the choice of drug (n = 44) or adherence to prophylaxis (n = 156). The characteristics of patients are listed in Table 1. Of the 272 febrile patients, 54 (19.8%) were diagnosed with imported malaria (= case ). Of these 54 cases of malaria, 36 were because of Plamodium falciparum (67%), AMP deaminase 14 cases to P vivax (26%), and 4 to P ovale (7%) (none for P malariae and P knowlesi) whereas 45 cases were acquired in sub-Saharan Africa (83%). The main diagnosis in the 218 controls were as follows: bacterial enteritis (n = 50), bacterial pneumonia (n = 20), infectious cellulitis (n = 20), pyelonephritis (n = 13), prostatis (n = 9), dengue fever (n = 16), viral (non HIV) primary infection (EBV, CMV, parvovirus B19) (n = 11), tuberculosis (n = 12), invasive schistosomiasis (n = 4), rickettsiosis (n = 3), brucellosis (n = 2), and primary HIV infection (n = 2). No diagnosis was made in 15 cases (5.5%) (Table 2). Overall an imported disease was diagnosed in 30.5% of these febrile patients.

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