14), and there was a trend of decreased severe complications (Grade 3–4) in the HDR group (30% LDR vs. 6% HDR; p = 0.06) (27). Other complications include chronic injury to bones and nerves. Bone fractures are reported in 0–4.5% of cases treated with BT (23). In the MSKCC randomized trial of BT vs. surgery alone, there was no significant difference in bone fracture risk between the two cohorts (p = 0.2) (34). The risk of bone fracture is increased with periosteal stripping or bone resection. Chronic neuropathy Forskolin clinical trial is reported in 0–10.1%, but overall it is not believed to be increased by BT [10], [34] and [45]. BT

has been described for treatment of recurrent sarcomas in a previously irradiated field. There is some controversy as to the benefit of reirradiation. Torres et al. reported on their retrospective series of WLE with or without further radiation in 62 patients. Twenty-five patients underwent WLE alone and 37 WLE and radiation. GKT137831 order Thirty-three of these patients underwent a single-plane BT implant. Radiation doses were 45–64 Gy. The 5-year DFS was 65% and LC 51%. Radiation, however, was not associated with improved LC, and they noted significant toxicity: 80% reoperation rate in the combined cohort vs. 17% with surgery alone (p < 0.001). The amputation rate, however, was 35% in the surgery-only group and 11% in the irradiated group (p = 0.05) (59). Catton et al.

(60) reported on 25 patients with recurrent sarcoma, 11 underwent conservative surgery alone, and 10 conservative surgery and irradiation (six cases BT only, one BT and EBRT, three EBRT only). The mean dose was 49.5 Gy (35–65 Gy). The overall LC at 24 months was 91%, but LC was better when radiation therapy was added to the surgery (36% vs. 100%). Wound healing complications Fenbendazole occurred in 60% of the cases. In spite of the wound healing problems, 70% were ultimately felt to have good functional outcome. Pearlstone et al. (61)

also reported on a series of 26 patients treated for local recurrence with a mean BT dose of 47.2 Gy. Local recurrence–free survival at 5 years was 52% and DFS 33%. The reoperation rate was only 15%, possible because 50% of the patients had up-front tissue transfer grafts. Retroperitoneal sarcomas present a major therapeutic challenge because of the high rate of local recurrence and the proximity of the OAR, which include the small bowel, kidneys, liver, stomach, and spinal cord. Radiation therapy appears to improve LC in patients with retroperitoneal sarcomas, and it is most commonly given with preoperative EBRT (62). Intraoperative radiation (IORT), using electron beam or HDR BT, has been evaluated as a means to improve LC [63], [64], [65] and [66]. The delivery of IORT is outside the scope of this article. The success however of IORT led to evaluations of postoperative BT in this population.