2011.156; published online 24 June 2011″
“Background. Continuity of care is considered by patients and clinicians an essential feature of good quality care in long-term disorders, yet there is general agreement that it is a complex concept. Most policies emphasize it and encourage systems to promote it. www.selleckchem.com/products/R406.html Despite this, there is no accepted definition or measure against which to test policies or interventions designed to improve continuity. We aimed to operationalize a multi-axial model of continuity of care and to use factor analysis to determine its validity for severe mental illness.
Method.
A multi-axial model of continuity of care comprising eight facets was operationalized for quantitative data collection from mental health service users using 32 variables. Of these variables, 22 were Subsequently entered into a factor analysis as independent components, using data from a clinical population considered to require long-term consistent care.
Results. Factor analysis produced seven independent continuity factors accounting for 62.5% of the total variance. These factors, Experience and Relationship, Regularity, Meeting Needs, Consolidation, Managed Transitions, Care Coordination and Supported Living, were close but not identical LY294002 nmr to the original theoretical model.
Conclusions. We confirmed that continuity of care is multi-factorial. Our seven factors are intuitively meaningful and appear to work in mental health. These factors
should
be used as a starting-point in research into the determinants and outcomes of continuity of care in long-term disorders.”
“Cadherins are a superfamily of cell surface glycoproteins whose ectodomains contain multiple repeats of beta-sandwich extracellular cadherin (EC) domains that adopt a similar fold to immunoglobulin domains. The best characterized cadherins are the vertebrate ‘classical’ cadherins, which mediate adhesion via trans homodimerization between their membrane-distal EC1 domains that extend from apposed cells, and assemble intercellular ever adherens junctions through cis clustering. To form mature trans adhesive dimers, cadherin domains from apposed cells dimerize in a ‘strand-swapped’ conformation. This occurs in a two-step binding process involving a fast-binding intermediate called the ‘X-dimer’. Trans dimers are less flexible than cadherin monomers, a factor that drives junction assembly following cell cell contact by reducing the entropic cost associated with the formation of lateral cis oligomers. Cadherins outside the classical subfamily appear to have evolved distinct adhesive mechanisms that are only now beginning to be understood.”
“Lenalidomide was shown to have significant single-agent activity in relapsed aggressive non-Hodgkin’s lymphoma (NHL). We conducted a phase I trial to establish the maximum tolerated dose of lenalidomide that could be combined with R-CHOP (rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone).