4%) still alive among the 141 women without tubal ligation (P < 0.001). Compared to the patients who

had no tubal ligation, the adjusted HR was 1.62 (95% CI 1.01-2.59; P = 0.04) for those who had tubal ligation. There was no association with age at menarche, menopausal status, parity, breastfeeding, hormone replacement therapy, oral contraceptive use, and hysterectomy.

Conclusion: Previous tubal ligation was an independently adverse prognostic factor for epithelial ovarian cancer survival. Further studies that examine the relationship are warranted GW2580 price to confirm these results.”
“Purpose: To investigate the antioxidant potential and cytotoxicity of the leaf and bark extracts of Tarchonanathus campharatus..

Methods: The antioxidant activity of the aqueous leaf extract (Aq LF), methanol leaf extract (MET LF), dichloromethane leaf extract (DCM LF), methanol bark extract (MET BK), dichloromethane bark extract (DCM BK), and ethyl acetate bark extract (Et Ac BK) were examined by 1,1-Diphenyl-2-picryl-hydrazil (DPPH), 2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(+)), nitric oxide radical scavenging, reducing power and iron chelating activity methods. Brine shrimp lethality and MTT cytotoxicity tests were

used to investigate the cytotoxicity of the extracts.

Results: The Aq LF, DCM LF, MET LF and MET BK showed good DPPH, ABTS radical scavenging and total reducing power activities. Total reducing power was high and in the rank order of DCM LF > Aq LF > MET LF > MET BK. All the CYT387 mw extracts, however, showed weak nitric oxide scavenging activity TH-302 purchase as well as weak iron chelating ability. Flavonoids, phenols, tannins and saponins were present in some of the extracts,

but alkaloids, terpenoids, cardenolides and cardiac glycosides were absent in all the extracts. All the extracts did not show significant cytotoxic properties (p >= 0.05) with 50% inhibitory concentration IC50 values > 30 mu g/ml in both cytotoxicity assays.

Conclusion: The antioxidant activity and low cytotoxicity of Tarchonanthus camphoratus probably justify its use in folk medicine.”
“Diverse preconditioning (PC) stimuli protect against a wide variety of neuronal insults in animal models, engendering enthusiasm that PC could be used to protect the brain clinically. Candidate clinical applications include cardiac and vascular surgery, after subarachnoid hemorrhage, and prior to conditions in which acute neuronal injury is anticipated. However, disappointments in clinical validation of multiple neuroprotectants suggest potential problems translating animal data into successful human therapies. Thus, despite strong promise of preclinical PC studies, caution should be maintained in translating these findings into clinical applications.