Age, gender, selective motor control and sport frequency of the immediate

family were included as covariates in the analyses when they changed the intervention effect by more than 10%. In total, 110 children with cerebral palsy were invited to participate, as presented in Figure 2. Fifty children agreed, signed an informed consent form and were randomised to either the experimental (n = 25) or control Selleckchem Ribociclib (n = 25) groups. Children were treated at 13 paediatric physiotherapy practices (n = 27) and three special schools for children with disabilities (n = 23). One child (control group) dropped out before baseline assessments due to unexpected botulinum toxin treatment. Three children (experimental group: n = 2, control group: n = 1) dropped out during the first 4 months of the intervention, and one child (control group)

missed the 4-month and 12-month assessments. Reasons for loss to follow-up are presented in Figure 2. The baseline characteristics of the participants are presented in Table 1 and in the first two columns of Table 2, Table 3, Table 4 and Table 5. The families in the experimental group received a median of five counselling sessions (range three to nine). An inventory of previously experienced mobility-related problems resulted in home-based physiotherapy for BYL719 nmr 14 of the 23 children in the experimental group. Adherence to the fitness training sessions was 91%, with children attending an average of 22 (SD 2, range 17 to 24) of the 24 training sessions. After a 3-week familiarisation period, training intensity of the loaded sit-to-stand increased from 79% (5.9 kg) of the predicted twelve-repetition maximum (ie, 10.6 kg)13 in the fourth week, to 116% (8.7 kg) in the eighth week, and to 141% in the final week. The intensity of the anaerobic exercises increased from the fourth to the last week according to the protocol, by reducing the work:rest ratio from 1:4 to 1:3 when performing five sets of 20-second exercises.13

Bumetanide No serious adverse effects were reported except for one child (female, GMFCS III) who reported hip complaints during the training. After taking rest (omitting two training sessions) and reduction of the training intensity, she was able to resume and complete the training program. Blinding was successful, with the assessor correctly guessing group allocation at a rate similar to chance throughout the trial. Some children did not complete all assessments on each occasion due to motivational problems or time constraints, as illustrated by the number of analysed cases in the tables. One child at 6 months, and four children at 12 months did not wear the accelerometer. No significant intervention effect was found for walking activity or for parent-reported physical activity at 6 months and 12 months (Table 2 and Table 3).