The disintegration test revealed that the all the liquisolid tablet were disintegrated within 15 min as shown in Table 5, which is as per specifications given for the uncoated tablets in the IP.12 Surface response graph of disintegration time [Fig. 2(B)] showing that as, as drug: excipient ratio

(R) and as drug conc. in liquid medication increases disintegration time is increased. Regression values of X1 and X2 for disintegration time were as shown in Table 4. Microcrystalline cellulose and sodium starch glycolate accelerates the disintegration of liquisolid compacts and improve dissolution of drug. Uniform drug content was observed for all the formulations (99.43 ± 0.53% to101.54 ± 1.56%), which is as per the IP specification (90–110%) as shown in Table 5. The results of in vitro drug released at different time intervals is plotted against time to obtain the dissolution profiles as shown in Fig. 7. The dissolution profiles of candesartan phosphatase inhibitor library cilexetil from liquisolid tablets (LS 1 to LS 9) produced higher drug dissolution rate in comparison with the conventional tablets (CND) in 0.05 M phosphate buffer PH 6.5. It was apparent

that LS 7 formulation has the highest dissolution rate. The percentage of candesartan cilexetil dissolved from LS 7 reached 101.44% after only 30 min, while the CND had maximum candesartan cilexetil content (35.81%) dissolved after 30 min. While CND had a maximum drug released of 59.33% 60 min. The enhanced dissolution rates of liquisolid compacts

compared to CND may be attributed to the fact that, the drug is already in solution in Tween 80, while at the same time, it is carried by the powder particles (microcrystalline cellulose and BMN 673 silica). Thus, drug release is accelerated due to its markedly increased wettability and surface availability to the dissolution medium which is the proposed mechanisms for explaining the enhanced dissolution rate from the liquisolid compacts. Tween 80 facilitates wetting of drug particles by decreasing interfacial tension between dissolution medium and tablet surface.17 Surface response graph of the percentage drug released at 30 min was shown in Fig. 2(C). From the surface response Thymidine kinase graph it is clear that drug release is decreased with an increase in concentration of drug in liquid medication. Regression values of X1 and X2 for in vitro drug release at 30 min were as shown in Table 4.The drug release properties of liquisolid compacts were improved with increasing powder excipients ratio (R). Therefore, the liquisolid tablets with high R values and lower drug conc. in liquid medication i.e. LS7 showed maximal drug release at 30 min i.e.101.44% while that of LS 3 had minimum of 70.76% drug release at 30 min. One way ANOVA is applied for the angle of repose, disintegration time, and in vitro dissolution. Statistical significance of effect of all these dependent variables was done by comparing the mean square against an estimate of the experimental error.