Adverse

events, en bloc resection rate, local recurrence were evaluated. Results: Of the 16 cases, there were 9 females and7 males. The age ranged from 41 to 82 years (average 58.8 years). En bloc STER was performed successfully in all 16 cases. The tumors location was 5–15 cm from the edge of anus. The resected specimen size was ranged from 1.0 to 3.5 cm (average 1.6 cm). The Small molecule library cell assay mean procedure time was 48 min (range 40–75 min). One patient developed mucosa perforation during STER procedure and was repaired with metal clips. Five patients developed low fever after procedure and all were managed by intravenous antibiotics. One patient developed subcutaneous emphysema in one of her legs and faded after two weeks. No delayed hemorrhage or severe adverse events occurred in any of the 16 patients following STER. Postoperative pathological examination revealed schwannoma (n = 4),

leiomyoma (n = 5), gastrointestinal stromal tumor (n = 5), proliferation of collagen fibers nodular degeneration (n = 3). All patients were hospitalized for observation after STER and the mean hospitalization duration was 4.0 days (range 2−14 days). Postoperative follow up ranged from 6 to 32 months (mean 21.1 months) and no residual lesion or recurrence was found. Conclusion: Our study showed that STER was safe and effective, provided accurate histopathologic evaluation, and was curative for rectal SMTs originating from muscularis Daporinad clinical trial propria layer in our initial experience. Further studies in more cases and on long-term outcome are awaited. Key Word(s): 1. submucosal tunneling endoscopic resection; 2. rectal submucosal tumors Presenting Author: MEI DONG XU Additional Authors: PING HONG ZHOU, LI QING YAO Corresponding Author: HUI LIU Affiliations: Zhongshan Hospital, Zhongshan Hospital Objective: To Sclareol investigate the managements of complications of submucosal tunneling endoscopic resection (STER) for the resection of upper gastrointestinal (GI) submucosal tumors (SMTs) originating from the muscularis propria (MP). Methods: A total of 290 patients with SMTs originating from the MP of the

upper GI tract who underwent STER between September 2010 and June 2013 were enrolled. The medical records were thoroughly investigated. Results: All SMTs were successfully resected with STER. The overall rates of en bloc resection and piecemeal resection were 95.4% and 4.6% respectively. The average size of the resected tumors was 21.0 ± 11.8 mm (range 10.0–70.0 mm). The mean time of STER procedure was 56 ± 38 minutes (range 15–200 minutes). Mucosal tear occurred in 3 cases (1.0%, 3/290) and large hemorrhage (blood loss >200 ml) occurred in 5 patients (1.7%, 5/290) during the operation. Subcutaneous emphysema occurred in 61 patients (21.0%, 61/290), 13 cases with air insufflation and 48 cases with CO2 insufflation.