Disclosures: The following people have nothing to disclose: Nisanne Ghonem, Meena Ananthanarayanan, Carol J. Soroka, James L. Boyer “
“The aim of this study was to clarify which or how factors could influence the

probability of sustained virological response (SVR) in 24-week telaprevir-based triple combination therapy for East Asian chronic hepatitis C patients infected with hepatitis C virus genotype 1b. Of 140 patients who were enrolled in this study, 137 received 12-week telaprevir combined with 24-week pegylated interferon alpha-2b plus ribavirin and were subjected to the analysis. Factors associated with SVR were analyzed by multiple logistic regression analysis. Of the 137 patients, 112 (82%) achieved SVR. Of 87 patients Rapamycin with IL28B single nucleotide polymorphism rs8099917 genotype TT, 84 (97%) achieved SVR. By contrast, 28 of 50 (56%) patients with the genotype TG/GG had SVR

(P = 3.29 × 10−9). Fifty-three of 60 (88%) naïve patients and 50 of 54 (93%) prior relapsers achieved SVR. Nine of 13 (69%) prior partial responders and none of 10 (0%) prior null responders achieved SVR. Multivariable analysis identified four independent factors that were significantly associated with SVR: IL28B SNP rs8099917 genotype (P = 6.90 × 10−5), pre-existence of cirrhosis (P = 3.99 × 10−3), prior treatment response (P = 0.0126), and rapid virological response (P = 0.0239). The IL28B single nucleotide polymorphism still remained informative as a predictor Nutlin-3a manufacturer of SVR to 24-week telaprevir-based triple combination therapy for East Asian patients infected with hepatitis C virus genotype 1b. Telaprevir is an

orally bioavailable peptidomimetic inhibitor of the hepatitis C virus (HCV) non-structural (NS) 3/4A serine protease.[1] Phases 2 and 3 studies conducted in the United States, Europe, and Japan have proved that this direct-acting antiviral agent (DAA) combined with pegylated interferon (peg-IFN) alpha-2a or -2b plus ribavirin (RBV) substantially increases the rate of sustained virological response (SVR) in treatment-naïve and previously treated patients infected with HCV genotype 1, albeit with higher rates of discontinuation because of adverse events, compared with peg-IFN alpha/RBV Bay 11-7085 combination alone.[2-10] Based on the proved efficacy and safety, the telaprevir-based triple therapy for chronic hepatitis C (CH-C) with HCV genotype 1 has been approved by each government organization.[11-13] Since November 2011, in Japan, patients have been receiving 12-week telaprevir in combination with 24-week peg-IFN alpha-2b/RBV by utilizing the government subvention. Numerous studies have reported that various host-, virus-, and treatment-related factors are associated with the outcome of peg-IFN alpha/RBV combination therapy for CH-C.