ESD for colorectal neoplasia was started in our hospital in 2010. The clinical data from our hospital will be reviewed to assess the efficacy and safety of endoscopic submucosal dissection of colonic neoplasms. Methods: From July 2010 to March 2013, 39 consecutive patients with early colorectal neoplasms were treated by ESD at Yuan’s General Hospital. Size of the colonic neoplasms, en-bloc resection rate, and complication rates were compared to several published data.

In addition, lesion sizes, type of lesions, complication, and procedure time were compared between the rectal vs non-rectal lesions in our study. Results: The mean age of the patients was 65.07 ± 9.50 years, and the male-female ratio Ponatinib molecular weight was 1.05 : 1. The mean tumor size was 32.5 ± 13.2 mm. The en-bloc resection rate was 87.8%, which is comparable to other studies performed in other centers. selleck chemical Perforations during ESD occurred in 2

patients (4.87%), which is slightly higher. However this could be a skewed data due to small sample size. Postoperative bleeding occurred in 1 patient (2.43%), and no delayed perforation recorded. There were no procedure-related morbidities or mortalities. Merely half (52.17%) of the LST in non-rectal neoplasms were non-granular type. All the LST in rectum were granular type in our study. Among all the lesions occurred in rectum, 61.10% turned out to be malignant; whereas only 21.7% were malignant in the non-rectal lesions. Rectal lesions required longer procedure time for removal; 73.28+/−61.76 minutes compared with 64+/−26.37 minutes for non-rectal lesion. This could be explained by the richer vasculatures in rectum that creates difficulties technically.

Conclusion: ESD is an effective method for en-bloc resection of large early colorectal neoplasms. Even though, our center commenced to perform ESD not so long ago, we have achieved comparable colonic ESD results 上海皓元 in terms of efficacy and safety compared to many other centers in Asia. Key Word(s): 1. ESD; 2. Colon; Presenting Author: YAN LIU Additional Authors: YANG SHI, WEIXIANG MENG Corresponding Author: YAN LIU Affiliations: Jilin University First Hospital Gastroenterology & Endoscopy Objective: Hirschprung disease is a digestive tract malformations, the basic pathogenesis of it is the lack of ganglia cell in the large bowel wall. The absence of these ganglia cell paralyzes the involved segment leading to cramps, narrow and intestinal contents through with difficulty. Almost patients are diagnosed when there are babies and operated upon in their first year. Hirschprung’s disease is a rare condition in the adult. Methods: A 58-year-old female came to the hospital because of bellyache and abdominal distension of 4 years duration, aggravating for 4 months, accompanied by constipation, vomit and the weight is reduced about 10 Kg in one month.