Females had lower risk of dying compared to males (HR=0.916, 95%CI: 0.881−0.952) and mortality increased with age at diagnosis (P<0.001, Table 1). There was no significant difference in OS across race/ethnicity groups (P=0.16, Table 1). Sex, race, grade/differentiation and MGC The effect of sex on OS was significantly varied by race and tumor differentiation in Pazopanib patients with MGC (P for interaction=0.003 and 0.005, respectively, Table 2). White and African American woman had significantly lower risk of dying compared to their male counterparts. In Asian, Hispanic,

and Native American populations, men and women had equivalent survival (Table 2.) Women also had a significantly lower risk of dying compared to males in patients Inhibitors,research,lifescience,medical whose tumors were poorly differentiated

or undifferentiated or had unknown Inhibitors,research,lifescience,medical tumor grade (Table 2). Table 2 Overall survival of patients with gastric cancer by sex, SEER data 1988-2004 Discussion This cohort of metastatic gastric cancer patients from the SEER database represents a wide cross-section of patients with variable socioeconomic and ethnic backgrounds. Our analysis also included a robust variety of pathology and is likely a more generalizable Inhibitors,research,lifescience,medical representation than can be found in clinical trials or case series. As expected, we found tumor characteristics such as grade, differentiation, and histology were associated with survival in advanced gastric cancer. Inhibitors,research,lifescience,medical Notably, there was a survival advantage attributable to gastric cardia lesions when compared to non-cardia lesions. This survival advantage persisted after controlling for the increased prevalence of cardia lesions in Caucasians and

men. Survival differences between cardia and non-cardia lesions may reflect differences in pathogenesis and tumor biology. H. pylori infection is recognized as a unique risk factor for non-cardia lesions while gastroesophageal reflux disease plays a role in the development of proximal lesions (38),(39). Interestingly, there is growing evidence that H2N expression is variably expressed in proximal and distal gastric cancer lesions (40). The proto-oncogene Her-2/neu (H2N) is Inhibitors,research,lifescience,medical located on chromosome 17q21 and encodes a transmembrane tyrosine kinase growth factor receptor featuring substantial homology with the EGFR (41),(42). Over-expression of the H2N protein has been identified in from 10 to 34% of breast cancers and is associated next with a poor prognosis (43). Over-expression of H2N has been reported in gastric and gastro-esophageal tumors (24). Additionally, there are studies describing H2N as a poor prognostic factor in gastric cancer (40). Further studies are needed to investigate its role in the development of proximal and distal gastric lesions. In addition to tumor characteristics, patient features, such as age and sex, also had significant prognostic impact. Ethnicity – often described in gastric cancer literature as having a prominent prognostic role – had no effect on survival.