He denied any new intimate partners, foods, or other exposures. The patient reported no history of previous symptomatic herpes simplex virus infection. His only significant medical history consisted of two episodes

of poison oak dermatitis. He was begun empirically on diphenhydramine and subsequently on acyclovir without improvement. Upon reexamination, the patient was noted to have developed cheilitis and angioedema of the face (Figure 1). The lips were edematous, eroded, and diffusely erythematous, predominantly on the left. An erythematous, nonblanching, buy Dasatinib pruritic rash with subcutaneous edema also had spread over his left face, extending up from his lips over his cheeks and nose and up to his orbits and forehead. Periorbital edema with ptosis was also apparent on the left side. He denied any tongue swelling and had no difficulty with speech, breathing, or swallowing. Upon further questioning, the patient acknowledged using his teeth to peel a mango for each of the previous 2 days, just as he had observed local children doing when a knife was not available. Because of the progression of his symptoms despite antihistamine c-Met inhibitor therapy, he was begun on prednisone with resolution of his symptoms within 48 hours. Mango contact allergy is more common in those with a history of poison ivy and poison

oak dermatitis, as these plants are closely related and mango sap contains the same uroshiol allergen.1,2 Travel medicine specialists should be aware of this well-described phenomenon and include this warning as part of their food safety counseling for travelers to tropical and subtropical regions, in addition to the usual education about the risk of fecal-oral pathogens from unwashed fruits and vegetables. I.

T. is supported by NIH training grant T32 HD049338. The authors state they have no conflicts of interest to declare. “
“A recent report documented the occurrence of dengue virus type-3 infection in a traveler returning from Benin. In their discussion, the authors mentioned the importance of the diagnosis of dengue fever in the Protein kinase N1 presence of other viruses like Lassa fever and yellow fever viruses endemic in the same areas. The authors did not offer any suggestions how to clinically differentiate infections with these viruses.[1] In a patient with pyrexia and hemorrhagic manifestations like mucosal bleeding, Lassa fever is compared with clinical manifestations of dengue and yellow fever very commonly characterized by a sore throat with white exudative patches in the pharynx. Common respiratory system involvement includes cough with underlying bronchitis or pneumonia.[2] In an endemic area, the combination of fever, exudative pharyngitis, retrosternal pain, and proteinuria made it possible to distinguish Lassa fever from other febrile illness with a positive predictive value of 80%.