He was initially treated with olanzapine 20 mg with some improvement, however adherence to medication was poor and his alcohol intake remained excessive. selleck compound Following trials with long-acting risperidone injection which did not lead to significant clinical improvement and subsequently a 6-month trial of flupenthixol decanoate depot and procyclidine, he asked to be treated with

olanzapine due to akathisia. After a second, short treatment course with oral olanzapine Inhibitors,research,lifescience,medical 20 mg, he was commenced on OLAI 300 mg every 2 weeks in June 2010 and attends an existing daycare service for his injections. There have been no further relapses or hospitalization over an 18-month period. The 2-weekly injections have led to more social involvement that has gradually led to improvement in his interactions in the daycare unit. Due to the degree of clinical improvement and good tolerability, dosage has not been reduced. He is accompanied to the clinic by a keyworker. Case 3 This case is a 61-year-old woman with a long history of chronic schizophrenia who has been hospitalized for Inhibitors,research,lifescience,medical the past 4.5 years. Management has proved difficult due to a variety of psychotic symptoms that have been diagnosed as De Clerambaults selleck chem syndrome (erotomania) and Capgras syndrome. Over 20 years, delusions have included having a relationship with the local priest and the death of her family and hospital staff,

Inhibitors,research,lifescience,medical including the consultant who has been replaced by an impostor. This has resulted in behaviours that have included significant paranoid and hostile interactions. Thus, management has been complicated, characterized by refusal to take any oral medication or Inhibitors,research,lifescience,medical to have blood tests. Treatments have included depot formulations of long-acting risperidone injection, flupenthixol decanoate, zuclopenthixol hydrochloride, haloperidol decanoate and pipothiazine Inhibitors,research,lifescience,medical palmitate. In March 2010, the patient was commenced on OLAI 300

mg every 2 weeks and remains on that dosage at the time of writing. Administration of OLAI and the 3 h observation period are undertaken at the daycare unit. The patient continues to be delusional and to refuse blood tests but the delusions are less intense with a reduction in the number of auditory hallucinations. She has become more socially interactive and has started to go to mass again. The clinical improvement is considered to be significant by the patient and staff. Daycare unit The unit is sited in an inpatient facility of a psychiatric hospital, Gransha Hospital, and has a mental Cilengitide health nursing and occupational therapy staff of five. All professionals have generic mental health skills, including mental health and risk assessment, and are appropriately qualified to observe patients for signs and symptoms of PDSS for at least 3 h post injection. The unit provides a broad treatment programme to adults with mental health issues as an alternative to home treatment or hospital admission and has 25 places. It is open to patients from 9 a.m. till 5 p.m.