Incidence rates for fatal infection were similar among anti-TNF biologic current exposure groups (0.78 to 0.88 per 1000 person-years). Incidence rates for fatal malignancy were similar among anti-TNF biologic initiator groups (1.24 to 1.84 per 1000 person-years).
Conclusions: The all-cause mortality rate in RA patients treated with anti-TNF biologics was lower than in previous studies in similar non-US populations, but comparable to mortality rates in the US general population. Fatal infection and fatal malignancy rates were similar across anti-TNF biologic groups. Further studies, designed Elafibranor to detect risk differences associated with anti-TNF biologic
use and baseline risk factors, would provide additional information. (C) 2012 Elsevier Inc. All rights reserved. Semin Arthritis Rheum 42:223-233″
“Objective-To determine whether veterinary-specific oscillometric blood pressure units yield measurements that are in good agreement with directly measured
blood pressures in cats.
Design-Evaluation study.
Animals-21 cats undergoing routine Rigosertib mw spaying or neutering.
Procedures A 24-gauge catheter was inserted in a dorsal pedal artery, and systolic, diastolic, and mean arterial pressures were directly measured with a validated pressure measurement system. Values were compared with indirect blood pressure measurements obtained with 3 veterinary-specific oscillometric blood pressure units.
Results-There was poor agreement between indirectly and directly measured blood pressures. For unit 1, bias between indirectly and directly measured values was -14.9 mm Hg (95% limits of agreement [LOA], -52.2 to 22.4 mm Hg), 4.4 mm Hg (95% LOA, -26.0 to 34.8 mm Hg), and -1.3 mm Hg (95% LOA, -26.7 to 24.1 mm Hg) for systolic, diastolic, and mean arterial pressures, respectively. For unit 2, bias was -10.3 mm Hg (95% LOA,
-52.9 to 32.2 mm Hg), 13.0 mm Hg (95% LOA, -32.1 to 58.0 mm Hg), and 9.1 mm Hg (95% LOA, -32.9 to 51.2 mm Hg) for systolic, diastolic, and mean arterial pressures, respectively. For unit 3, bias was -13.4 mm Hg (95% LOA, -51.8 to 25.1 mm Hg), 8.0 mm Hg (95% LOA, -25.5 to 41.6 mm Hg), and -3.6 mm Hg (95% LOA, -31.6 to 24.5 mm Hg) for systolic, diastolic, JQ1 nmr and mean arterial pressures, respectively.
Conclusions and Clinical Relevance-Results suggested that none of the 3 veterinary-specific oscillometric blood pressure units could be recommended for indirect measurement of blood pressure in cats. (J Am Vet Med Assoc 2010;237:402-406)”
“Objective: To investigate whether rheumatoid arthritis (RA) and psoriatic arthritis (PsA) can be differentiated in the early stages of the disease (duration of symptoms <= 1 year) on the basis of magnetic resonance imaging (MRI) features of the hand and wrist.
Material and methods: Twenty early RA and 17 early PsA patients with symptomatic involvement of the wrist and hand joints and inconclusive radiographic studies were examined prospectively with contrast-enhanced MRI.