inhibition of PI3K Akt mTOR signaling provides encouraging methods of prevention and therapies for prostate cancer. mTOR kinds two functional complexes, C1 and C2, and combines signals from cellular energy status, growth facets, and nutrients to control cell growth and growth by regulating protein synthesis. Phosphorylation of mTOR at Ser2448 by Akt or S6K1 and at Ser2481 by automobile phosphorylation is essential because of its activity. The game of mTOR is negatively controlled by tuberous aurora inhibitorAurora A inhibitor sclerosis complex 1 and 2. TSC1/TSC2 complex dissociates Ras homolog enriched in brain from mTOR, hence prevents mTOR service. Akt phosphorylates TSC2 and disrupts the TSC1/ TSC2 complex, leading to activation of mTOR. On another hand, 5 AMP activated protein kinase, that is activated by elevated AMP/ATP ratio and/or tumor suppressor LKB1, inhibits mTOR activation by activating TSC1/TSC2. Triggered mTOR C1 phosphorylates the translation inhibitor 4e-bp1 and the ribosomal protein S6 kinase, in initiation of protein translation. p70 S6K also phosphorylates and inhibits insulin receptor substrate 1, forms an adverse feed back regulation of PI3K/Akt signaling. The PI3K/Akt/mTOR path can also be controlled by serine/threonine protein phosphatases. Two main lessons of serine/threonine skeletal systems protein kinases, PP2A and PP1, are extensively involved in several signaling pathways. It has been well documented that PP2A interacts with and dephosphorylates Akt in vitro and in vivo. PP2A has also been noted to dephosphorylate S6K in response to different stimuli. Similarly, 4e-bp1 has been defined as a substrate of PP2A in vitro and in vivo. Currently no direct evidence proves that mTOR is dephosphorylated by PP2A. However, research using adenovirus suggested Oprozomib clinical trial that mTOR activity is regulated by PP2A, and mTOR can also be active in the regulation of PP2A activity. Compare to PP2A, PP1 is less involved with Akt/mTOR signaling, probably due to the absence of PP1 recognition sequences and docking motifs within the major aspects of Akt/mTOR signaling. Besides PP2A and PP1, PH site leucine prosperous repeat protein phosphatase 1 and 2 have now been defined as particular Akt S473 phosphatases In lots of human cancers, specially prostate cancers, PI3K/Akt/mTOR signaling is dysregulated by different oncogenic events. The hormone refractory prostate cancers are frequently seen as a activation of Akt/mTOR signaling and inactivation of PTEN. Akt activity can be an crucial determinant of the sensitivity of prostate cancer cells to treatments. Curcumin, an important chemical part of turmeric, use a broad-spectrum of therapeutic and chemopreventive properties against various tumors in both in vitro and in vivo models and clinical trials. Curcumin has demonstrated an ability to inhibit cell growth, cause apoptosis, control inflammation, and sensitize tumefaction cells to cancer treatments.