Oncol Rep 2012,28(4):1503–1511.PubMed 15. Zhang X, Chen T, Zhang J, Mao Q, Li S, Xiong W, Qiu Y, Xie Q, Ge
J: Notch1 Promotes Glioma Cell Migration and Invasion by Stimulating β‒catenin and NF‒κB Signaling via AKT Activation. Cancer Sci 2012,103(2):181–190.PubMedCrossRef 16. Li XJ, Ji MH, Zhong SL, Zha QB, Xu JJ, Zhao JH, Tang JH: MicroRNA-34a Modulates Chemosensitivity of Breast Cancer Cells to Adriamycin by Targeting Notch1. Arch Med Res 2012,43(7):514–521.PubMedCrossRef 17. Xie M, Liu M, He CS: SIRT1 regulates endothelial Notch signaling in lung cancer. PLoS One 2012,7(9):e45331.PubMedCrossRef 18. Guo Z, Jin X, Jia H: Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that Momelotinib of gamma-secretase in renal carcinoma. J Exp Clin Cancer Res 2013, 32:26.PubMedCrossRef 19. Su C, Chen Z, Luo H, Su Y, Liu W, Cai L, Wang T, Lei Y, Zhong B: Different patterns of NF-kappaB and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma. J Exp Clin Cancer Res 2011, 30:85.PubMedCrossRef 20. Kim A, Kim EY, Cho EN, Kim HJ, Kim SK, Chang J, Ahn CM, Chang YS: Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer. Oncology reports 2013,30(3):1423–1429.PubMed
21. Zheng Q, Qin H, NVP-BGJ398 solubility dmso Zhang H, Li J, Hou L, Wang H, Zhang X, Zhang S, Feng L, Liang Y, Han H, Yi D: Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549. Oncol Rep 2007,17(4):847–852.PubMed 22. Chen Y, Li D, Liu H, Xu H, Zheng H, Qian F, Li W, Zhao C, Wang Z, Wang X: Notch-1 signaling facilitates survivin expression in human non-small cell lung
cancer cells. Cancer biology & therapy 2011,11(1):14–21.CrossRef 23. Chen Y, De Marco MA, Graziani I, LY2874455 supplier Gazdar Aurora Kinase AF, Strack PR, Miele L, Bocchetta M: Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung. Cancer research 2007,67(17):7954–7959.PubMedCrossRef 24. Xia W, Wong ST, Hanlon E, Morin P: γ-Secretase Modulator in Alzheimer’s Disease: Shifting the End. J Alzheimers Dis 2012,31(4):685–696.PubMed 25. Strosberg JR, Yeatman T, Weber J, Coppola D, Schell MJ, Han G, Almhanna K, Kim R, Valone T, Jump H: A phase II study of RO4929097 in metastatic colorectal cancer. Eur J Cancer 2012,48(7):997–1003.PubMedCrossRef 26. Licciulli S, Avila JL, Hanlon L, Troutman S, Cesaroni M, Kota S, Keith B, Simon MC, Puré E, Radtke F: Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. Cancer research 2013,73(19):5974–5984.PubMedCrossRef 27. Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL: Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry. PLoS One 2013,8(6):e67306.PubMedCrossRef Competing interests The authors declare that they have no competing of interests.