Results from Selleckchem Dibutyryl-cAMP scanning electron microscope shows that all the SF microparticle matrices were porous structures. Using ethyl acetate and diethyl ether as the oil phase gave larger SF microparticle sizes than using dichloromethane and chloroform. The influences of water/oil volume ratio and the SF concentration showed slightly effect
on the sizes of SF microparticles. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 118: 1127-1133, 2010″
“The qualification process for ensuring that a paddle or basket apparatus is suitable for its intended use is a highly debated and controversial topic. Different instrument qualification and suitability methods have been proposed by the pharmacopeias and regulatory bodies. In an effort to internationally harmonize dissolution apparatus suitability requirements, the International Pharmaceutical Federation’s (FIP) Dissolution/Drug
Release Special Interest Group (SIG) reviewed current instrument suitability requirements listed in the US, European, and Japanese pharmacopeias and the International Conference on Harmonization (ICH) Topic Q4B on harmonization of pharmacopoeial methods, in its Annex 7, Dissolution Test General. In addition, the SIG reviewed the Food and Drug Administration (FDA) Draft Guidance for Industry, “”The Use of Mechanical Calibration of Dissolution Apparatus 1 and 2-Current Good Manufacturing
GSK1904529A Practice (CGMP)”" and the related ASTM Standard E2503-07. Based on this review and several in-depth discussions, the FIP Dissolution/Drug Release SIG recommends that the qualification of a dissolution test instrument should be performed following the calibration requirements as indicated in the FDA (draft) guidance. If additional system performance information is desired, a performance verification test using US Pharmacopeia Reference Standard tablet or an established in-house reference product can be conducted. Any strict requirement on the use of a specific performance verification test tablet is not recommended at this time.”
“We present an advanced analytical model which applies to light beam induced current contrast profiles to determine reliably the effective surface recombination velocities BMS-777607 ic50 (S(eff)) of grain boundaries (GBs) and diffusion lengths (L(diff)) in the grains, in cases where a GB is close to the studied one or when L(diff) of the neighboring grain differs. We introduce additionally a new method for a very accurate determination of the plateau value of the investigated linescan and make use of simultaneously fitting GB profiles measured at various laser wavelengths both aiming at increasing the accuracy of the L(diff) determination. Through several special case investigations, the various applications and limitations of the model are demonstrated.