The median duration of NRTI use was 77 (IQR 20–149) months, that of NNRTI use was 17 (IQR 0–51) months, and that of PI use was 26 (IQR 0–75) months. Nineteen per cent of participants were currently receiving abacavir. Seventy-five participants (34%) had a positive CAC score and 17 (8%) had a CAC score of >100, indicating significant atherosclerotic disease (Fig. 1). Fatty liver disease on TSA HDAC order CT imaging was diagnosed in 29 HIV-infected persons (13%). The prevalence of fatty liver disease among those without CAC, those with a CAC score of 1–100, and those with a score >100 was 8, 18 and 41%, respectively (P=0.001). Of those with fatty liver disease, 59% (17

of 29) also had coronary atherosclerosis as determined by CAC>0, and these two conditions were significantly correlated (r=0.21, P=0.002). The prevalence of a positive www.selleckchem.com/products/obeticholic-acid.html CAC score among those 35–49 years of age in our cohort was 31% (36 of 116), with 6% having a CAC score of >100 (Fig. 1). Similar relationships between fatty liver disease and a positive CAC score were also noted in this age group. Regarding clinical symptoms, participants with a positive CAC score were not significantly more likely to report a history of chest pain or dyspnoea compared with those without CAC (21%vs. 17%, respectively; P=0.46). For HIV-infected persons with low (<10%), moderate (10–20%)

and high (>20%) FRSs, a positive CAC scan was noted in 27, 63 and 60% of patients, respectively (P<0.01) (Table 2). The median FRS for those with a positive

CAC was 8 (IQR 3–12), while those without CAC had a median 17-DMAG (Alvespimycin) HCl score of 3 (IQR 1–6) (P<0.01). Of note, the majority (64%) of those with a positive CAC score had a low FRS. We assessed the utility of the FRS for predicting positive CAC scores (it should be noted that the CAC test is a noninvasive test for detecting calcified coronary disease, and, unlike the gold standard diagnostic test, coronary catheterization, it may miss noncalcified plaque). The sensitivity, specificity, and positive and negative predictive value of the FRS in predicting a positive CAC score in HIV-infected persons were 36%, 89%, 63% and 73%, respectively. In the univariate analyses, HIV-infected persons with CAC compared with those without CAC were older (median 49 vs. 40 years old, respectively; OR 1.2; P<0.01), were more likely to be Caucasian (64%vs. 42%, respectively; OR 2.0; P=0.04), had a longer duration of tobacco use (median 18 vs. 10 years, respectively; OR 1.1 per year; P<0.01), were more likely to be receiving lipid-lowering medication (51%vs. 22%, respectively; OR 3.7; P<0.01) and were more likely to have diabetes (13%vs. 3%, respectively; OR 5.5; P<0.01), hypertension (49%vs. 20%, respectively; OR 4.0; P<0.01), the metabolic syndrome (35%vs. 16%, respectively; OR 2.8; P<0.