681 0.055 buy GSK2879552 Weston (Caucasian) 6 27 32 3 42 72 1.189 0.276 Weston (African) 6 9 1 12 14 4 0.001 0.979 Li 11 11 6 10

26 14 0.109 0.741 Wang-Gohrke 282 221 49 300 203 40 0.485 0.486 Buyru 64 39 12 21 43 12 1.657 0.198 Huang 64 100 36 114 138 30 1.545 0.214 Katiyar 20 51 6 9 24 8 1.205 0.272 Mabrouk 18 9 3 19 26 4 1.432 0.231 Kalemi 26 13 3 10 32 9 3.326 0.068 Tommiska 825 617 109 403 278 52 0.183 0.669 Baynes 1107 768 148 1177 854 166 0.414 0.520 Gochhait 86 109 48 76 160 97 0.413 0.521 Khadang 83 109 29 75 90 40 1.873 0.171 Schmidt 2797 2008 386 2024 1523 287 0.001 Compound Library cell assay 0.983 Sprague 823 570 89 705 490 83 0.03 0.862 Zhang 21 45 17 47 find more 87 33 0.406 0.524 Akkiprik 25 50 20 46 49 12 0.038 0.846 Test of heterogeneity We analyzed the heterogeneity of Arg/Arg versus Pro/Pro and dominant

model (Arg/Arg+Arg/Pro versus Pro/Pro) as well as recessive model (Arg/Arg versus Arg/Pro+Pro/Pro). of cases/controls Arg/Arg vs Pro/Pro (Arg/Arg+Arg/Pro) vs Pro/Pro Arg/Arg Oxalosuccinic acid vs (Arg/Pro+Pro/Pro)     OR (95%CI) P P (Q-test) OR (95%CI) P P (Q-test) OR (95%CI) P P (Q-test) Random-effect model Total 12226/10782 1.20 (0.96–1.50) 0.11 0.000 1.12 (0.96–1.32) 0.14 0.01 1.13 (0.98–1.31) 0.10 0.000 Caucasian 11549/9830 1.15 (0.91–1.44) 0.24 0.001 1.11 (0.95–1.30) 0.17 0.06 1.09 (0.93–1.27) 0.28 0.000 Asian 631/873

1.36 (0.61–3.03) 0.45 0.000 1.19 (0.67–2.10) 0.55 0.006 1.22 (0.72–2.05) 0.46 0.002 African 46/79 1.46 (0.38–5.62) 0.58 0.76 1.12 (0.31–4.10) 0.86 0.45 1.60 (0.63–4.06) 0.32 0.22 Fixed-effect model Total 12226/10782 1.09 (0.99–1.20) 0.10 0.000 1.09 (0.99–1.19) 0.06 0.01 1.04 (0.99–1.10) 0.13 0.000 Caucasian 11549/9830 1.07 (0.96–1.18) 0.24 0.001 1.08 (0.98–1.19) 0.12 0.06 1.03 (0.98–1.09) 0.25 0.000 Asian 631/873 1.27 (0.94–1.71) 0.12 0.000 1.16 (0.89–1.51) 0.26 0.006 1.15 (0.92–1.44) 0.22 0.002 African 46/79 1.47 (0.39–5.62) 0.57 0.76 1.17 (0.33–4.14) 0.80 0.45 1.67 (0.80–3.48) 0.17 0.22 Meta-analysis results Table 3 lists the main results of the meta-analysis.